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今天的文献速递内容主要有：

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幽门螺杆菌感染、慢性萎缩性胃炎与胃癌和食道癌的风险：基于前瞻性人群的Esther队列研究结果

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阳性淋巴结对数比预测食管切除术后接受新辅助治疗的患者的存活率

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预防性胸管结扎术与食管鳞癌预后不良和区域淋巴结复发有关

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Helicobacterpyloriinfection,chronicatrophicgastritisandriskofstomachandesophaguscancer:Resultsfromtheprospectivepopulation-basedESTHERcohortstudy.

幽门螺杆菌感染、慢性萎缩性胃炎与胃癌和食道癌的风险：基于前瞻性人群的Esther队列研究结果

Helicobacterpylori(H.pylori)infectionisconsideredasprincipalcauseofgastriccancer.Itisfurtherassociatedwithareducedriskofesophagealadenocarcinomas.Inalargeprospectivepopulation-basedcohortstudyincluding9,subjectswithaverageobservationtimeof13.8years,weassessedtheriskofinvasivegastricandesophagealcanceraccordingtoH.pyloriinfectionandpresenceofchronicatrophicgastritis(CAG).Incidenceratesandhazardratios(HR)derivedbyCoxproportionalhazardsmodelsandadjustedforrelevantconfounderswerederivedbyseroprevalenceofH.pyloriandcytotoxin-associatedgeneA(CagA)antibodiesandpresenceofCAGbasedonserologicalmarkersatbaseline,respectively.Duringfollow-up,30casesofnoncardiagastriccancerand33casesofesophagealcancerwereobserved.InfectionbyH.pyloriwithoutandwithexpressionofCagAwasassociatedwitha5.2-fold(95%confidenceinterval1.00-27.1)andan18.2-fold(4.3-77.4)increaseofnoncardiagastriccancerincidence.A0.65-folddecreasedriskofesophagealadenocarcinomas(HR0.35,0.12-0.97)wasobservedamongH.pylori-infectedindividuals.InparticipantsinfectedwithCagAexpressedH.pylori,thepresenceofmild/moderateandsevereCAGwasassociatedwitha6.4-fold(1.3-31.0)andan11.8-fold(3.1-45.4)increaseofgastriccancerincidence,respectively.Theresultsofthisprospectivepopulation-basedcohortstudymaycontributerelevantevidencetotheongoingresearchofH.pylori-relatedcancers.TheresultsmayfurthermoreenhancetheempiricalbasisforriskstratificationamongH.pylori-infectedpeopleandforre
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